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As mentioned, Ketamine SLC can be abused recreationally though the drug itself has no withdrawal syndrome in the same sense as opiates. Ketamine’s use outside of that of an anesthetic is considered off label and, as with all off label medicines, is allowed when deemed medically appropriate by an attending physician. For perspective, note that estimates suggest that almost ¼ of all prescription medications sold in the United States are prescribed with off label intention.